Mind-body therapies reduce markers of inflammation and influence virus-specific immune responses to vaccination despite minimal evidence suggesting effects on resting anti-viral or enumerative measures.
Author
information
Abstract
IMPORTANCE:
Psychological
and health-restorative benefits of mind-body therapies have been investigated,
but their impact on the immune system remain
less defined.
OBJECTIVE:
To
conduct the first comprehensive review of available controlled trial evidence
to evaluate the effects of mind-body therapies on the immune system,
focusing on markers of inflammation and anti-viral related immune responses.
METHODS:
Data
sources included MEDLINE, CINAHL, SPORTDiscus, and PsycINFO through September
1, 2013. Randomized controlled trials published in English evaluating at least
four weeks of Tai Chi, Qi Gong, meditation, or Yoga that reported immune outcome measures were selected.
Studies were synthesized separately by inflammatory (n = 18), anti-viral
related immunity (n = 7), and enumerative (n = 14) outcomes measures. We
performed random-effects meta-analyses using standardized mean difference when
appropriate.
RESULTS:
Thirty-four
studies published in 39 articles (total 2, 219 participants) met inclusion
criteria. For inflammatory measures, after 7 to 16 weeks of mind-body
intervention, there was a moderate effect on reduction of C-reactive protein
(effect size [ES], 0.58; 95% confidence interval [CI], 0.04 to 1.12), a small
but not statistically significant reduction of interleukin-6 (ES, 0.35; 95% CI,
-0.04 to 0.75), and negligible effect on tumor necrosis factor-α (ES, 0.21; 95% CI, -0.15 to 0.58). For anti-viral
related immune and enumerative measures, there were
negligible effects on CD4 counts (ES, 0.15; 95% CI, -0.04 to 0.34) and natural
killer cell counts (ES, 0.12, 95% CI -0.21 to 0.45). Some evidence indicated
mind-body therapies increase immuneresponses to vaccination.
CONCLUSIONS:
Mind-body
therapies reduce markers of inflammation and influence virus-specific immune responses to vaccination despite
minimal evidence suggesting effects on resting anti-viral or enumerative
measures. These immunomodulatory effects, albeit incomplete, warrant further
methodologically rigorous studies to determine the clinical implications of
these findings for inflammatory and infectious disease outcomes.
Learn more about the predecessor of Tai Chi, Shaolin Rou Quan
Learn more about the predecessor of Tai Chi, Shaolin Rou Quan
Original source:
http://www.ncbi.nlm.nih.gov/
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου